1. When did Sulfa "hit" the market?
a. 1920's
b. 1940's
c. 1950's
*d. 1930's

2. During WW II which country started "rediscovering" the effects of Penicillin?
*a. England
b. Germany
c. United States
d. France
e. none of the above

3. Who actually discovered compound 606, also known as salvarsan?
a. Robert Koch
b. Louis Pasteur
c. Alexander Fleming
*d. Paul Ehrlich

4. A compound synthesized by bacteria or fungi that destroys or inhibits the growth of other microbes is a/an
a. Synthetic drug
*b. antibiotic
c. antimicrobic drug
d. competitive inhibitor

5. Which of these are involved in osmotic lysis of the cell well?
a) Penicillins
b) Cephalosporins
c) Cycloserine
d) Vancomycin
*e) All of the above
f) None of the above

6. Which of these drugs do not affect the nucleic acid synthesis?
a) Sulfonamides
b) Trimetoprim
*c) Polymyxins
c) Chloroquine
d) Quinolones
e) acyclovir

7. Which drugs are competitive inhibitors by occuping the binding site of the enzyme and blocking the substrate from the site?
*a) Sulfonamides (sulfa drugs) and trimethoprim
b) Cycloserine and vancomycin
c) Amphotericin B and nystatin

8. Do beta-lactam drugs destroy all of the targeted bacteria cell wall? If not, then why? Why are not human cells effected?
a) No
b) Old, inactive, dormant cells not susceptible because they are not making new peptidoglycan
*c) Peptidoglycan is part of bacterial cell walls, but is not found in humans

11. Chemotheraputic agents are described with regard to:
a. origin
b. range of effectiveness
c. naturally produced
d. chemiclly synthesized
*e. all of the above

12. Which would be the best drug spectrum for both gram + and gram - bacteria?
a. narrow spectrum
*b. medium spectrum
c. broad spectrum

13. What inhibits DNA unwinding enzymes or helicases?
a. Penicillin
*b. Chloroquine
c. Acyclovir
d. Azidothymidine

14. Tetracycline blocks the attachment of
a. mRNA
b. inhibition of 30s subunit ribosome
*c. tRNA
d. inhibition of 50s subunit ribosome

15. The first Penicillin was the patent for all other "cillins"
a. V
*b. G
c. A
d. C

16. The adverse effect of tetracycline given to young children is...
a. allergies
b. joint damage
*c. discoloration of teeth
d. dependency on drug


17. Which of these drugs comes from a mold microbe?
a. Aztreonam
b. Bacitracin Polymixin B
*c. Cephalosporins
d. Gentamicin

18. Of these Penicillin drugs which one has the poor absorption and growing resistance?
a. Penicillin G
*b. Methicillin
c. Amoxicillin
d. Mexlocillin

19. Drugs that prevent the formation of the bacterial cell wall are
a. quinolones
*b. beta-lactams
c. tetracyclines
d. aminoglycosides

20. Most antiheminthic drugs function by
*a. weakining the worms so they can be flushed out by the intestine
b. infibiting worm metabolism
c. blocking the absorption of nutrients
d. inhibiting egg production

21. A patient has a red circular rash on his arm and fever, malaise, and joint pain. The most appropriate treatment is
*a. penicillin.
b. chloroquine.
c. anti-inflammatory drugs.
d. rifampin.
e. no treatment.